If you need to prepare the mixture youll inject, follow the directions provided. If you use alprostadil (either by injection or suppository) and have sex with a pregnant woman, use a condom. Erectile dysfunction (sometimes called impotence) means that you cannot get or maintain a proper erection. What conditions does Alprostadil Suppository treat. The suppository contains the drug alprostadil, which has been available for several years as an intracavernous injection. alprostadil 250 MCG Urethral Suppository is also used to improve blood flow in newborn babies with a certain genetic heart condition. These materials provide visual instruction and more detailed information as well as practical tips on how to use MUSE. If any of the information is unclear, consult your doctor or pharmacist. For instance, keep it out of warm, moist settings (such as the bathroom). Long-term carcinogenicity studies of alprostadil have not been conducted. This allows more blood to flow to your penis to encourage an erection. If any of the information is unclear, consult your doctor or pharmacist. Do not freeze. Human seminal fluid is a rich source of prostaglandins, including PGE1 and PGE2, and the total concentration of prostaglandins in ejaculate has been estimated to be approximately 100-200 mcg/mL. USES: This medication is used to treat male sexual function problems (erectile dysfunction). What is Muse (alprostadil) used for? This product is available in the following dosage forms: There is a problem with MUSE is available in 4 dosage strengths: 125 mcg, 250 mcg, 500 mcg, and 1000 mcg. It is unknown whether this adverse event experienced by female partners was a result of the medication or a result of resuming sexual intercourse, which occurred much more frequently in partners of patients on active medication. About 10%, 20%, 30%, and 40% of patients were titrated to 125 mcg, 250 mcg, 500 mcg, and 1000 mcg, respectively. If used, ice packs should be applied alternately to each inner thigh for a period not exceeding 10 minutes. Alprostadil (Muse) received an overall rating of 9 out of 10 stars from 4 reviews. This medicine should only be used as needed to achieve an erection. MUSE should not be used if the female partner is pregnant, unless the couple uses a condom barrier. Because of the potential for these side effects, MUSE titration should be carried out under medical supervision. Intravenous doses of 1 to 10 micrograms per kilogram of body weight lower blood pressure in mammals by decreasing peripheral resistance. Very effective for patients who are experiencing erectile dysfunction secondary to radical prostatectomy. This does not apply. Only 50 patients (4.3%) discontinued treatment because of a TRAE, and only four (0.3%) discontinuations were due to the partner. Please read patient instruction leaflet regarding usage and storage. MUSE may be kept by the patient at room temperature (below 30C or 86F) for up to 14 days prior to use. Alprostadil cream carries all the exact same risks as injections, pellets, etc. Protect from heat and light. However, due to efficacy, cost, and side effects, it is not used often. It is used to treat erectile dysfunction (ED). MUSE should be used as needed to achieve an erection. health information, we will treat all of that information as protected health WebMD does not provide medical advice, diagnosis or treatment. Do not share this medication with others. Set the bottles on a clean surface. COMMON BRAND NAME (S): Muse Cleveland Clinic is a non-profit academic medical center. Do not open until you are ready to use it. We do not endorse non-Cleveland Clinic products or services. Alprostadil urethral suppository. NOTE: This medicine is only for you. Human semen contains PGE1, but additional amounts may be present from MUSE administration (see CLINICAL PHARMACOLOGY). Because MUSE has not been tested during human pregnancy, it is recommended that couples use adequate contraception if the female partner is of childbearing potential. After administration, the erection process will begin within 5 10 minutes, and may last 30 60 minutes. Product details Does Alprostadil Suppository interact with other drugs you are taking? The suppository form is not as effective. This medicine causes an erection because it increases the blood flow to the penis. Talk to your health care provider for more information. Alprostadil intracavernosal injection cartridge devices are designed for one time use. While Alprostadil is often administered via an injection, this specific medication also comes in a suppository. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. If you are a Mayo Clinic patient, this could Its only available by prescription. However, the actual duration will vary from patient to patient. Choosing between the injection and suppository is a personal choice. MUSE and MEDA PHARMACEUTICALS are registered trademarks, and theMEDA PHARMACEUTICALS logo is a trademark of Meda AB or a related entity. Before using alprostadil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Before administering MUSE, please review the patient video and education booklet. Tell your doctor right away if any of these unlikely but serious side effects occur: fainting. Using a water-based lubricant can help to make vaginal penetration easier. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through subtunical vessels is impeded and penile rigidity develops. Use it as directed on the prescription label. You will be taught how to prepare and use it. USES: This medication is used to treat male sexual function problems (erectile dysfunction). We have been in business since 2009 and have the lowest prices worldwide. Alprostadil is also used to improve blood flow in . The risk of priapism (erections that last too long) aren't just a matter of "overdosing." It can happen with the normally accepted dose regardless of the manner in which it is delivered. It belongs to a group of medicines called vasodilators that can increase blood flow by expanding blood vessels. MUSE- alprostadilsuppository See what others have said about Alprostadil (Muse), including the effectiveness, ease of use and side effects. After I administer MUSE, can we immediately lie down and begin sexual activity? However, the actual duration will vary from patient to patient. Alprostadil urethral suppository May 06, 2021 . The following table summarizes the frequency of adverse events reported by patients using MUSE or placebo. Somerset, New Jersey 08873-4120. http://www.muserx.net Catalog Number: 05-10-00000FIS-1001-04Revised: 4/20182018 Mylan Specialty L.P. MUSE It is assumed that you and your doctor have determined the proper dose of MUSE. Following MUSE administration, alprostadil is absorbed from the urethral mucosa into the corpus spongiosum. 996 patients (66%) completed dose titration, achieved an erection sufficient for intercourse, and were randomized equally to placebo or active treatment and followed during at-home treatment for up to 3 months. MUSE is an acronym of Medicated Urethral Suppository for Erection and is classed as a medicated pellet and is administered using a plastic applicator. Do not use more than 2 times in each 24-hour period. Alprostadil 2/8 Please note: This is a refrigerated product, and it can only be shipped using our EMS courier option. What are the side effects associated with MUSE? Its solubility at 35C is 8000 mcg per 100 mL double-distilled water. Call your doctor for medical advice about side effects. This medication is used by inserting the suppository into the penis as directed by your doctor. Policy, Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Visitation, mask requirements and COVID-19 information. These materials provide visual instruction and more detailed information as well as practical tips on how to use MUSE. Learn all usage instructions in the product package. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: "blood thinners" (such as warfarin, heparin), high blood pressure medicines. (See also: WHAT ARE THE POSSIBLE SIDE EFFECTS OF MUSE? on the other side.). MUSE is administered by inserting the applicator stem into the urethra after urination. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. information and will only use or disclose that information as set forth in our notice of Alprostadil is a white to off-white crystalline powder with a melting point between 110 and 116C. If this drug is used by a male for sexual intercourse with a pregnant woman, an effective barrier method such as a latex or polyurethane condom should be used. Sit, stand, or walk for 10 minutes to boost blood flow to your penis to help with an erection. Distributed by: Prostaglandin E1 is a naturally occurring acidic lipid that is synthesized from fatty acid precursors by most mammalian tissues and has a variety of pharmacologic effects. the unsubscribe link in the e-mail. This allows an increase in blood flow that will give you an erection. Drug information provided by: IBM Micromedex. Penis/testicle/groin pain, minor bleeding or spotting from the penis, dizziness, swelling (especially of leg veins), and rapid heartbeat may occur. MUSE is administered by inserting the applicator stem into the urethra after urination. If you feel dizzy, light-headed, faint, or experience rapid pulse, lie down immediately and raise your legs. MUSE is intended for single-dose application only. For Alprostadil Suppositories. 1998-2022 Mayo Foundation for Medical Education and Research (MFMER). Alprostadil is also used to treat erectile function. Patients should be informed that MUSE offers no protection from the transmission of sexually transmitted diseases. Call your doctor if you suspect you may require a dosing adjustment. The chemical name for alprostadil is prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-(11,13E,15S)-(1R,2R,3R)-3-hydroxy-2-[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxo-cyclopentane heptanoic acid, and the molecular weight is 354.49. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. An effective dose of MUSE should produce an erection sufficient for sexual intercourse. Canada residents can call a provincial poison control center. Find out about COVID-19, COVID-19 vaccines, and Mayo Clinic patient and visitor updates. MEDA MUSE is available in unit cartons containing six (6) systems. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Wash your hands before and after use. Most of the side effects reported in men are relatively minor and include burning and aching in the penis and groin. PHARMACEUTICALS Brand Name: Muse. It relaxes the blood vessels and muscles in your penis. Brand/Generic (GENERIC) ALPROSTADIL Form VIAL Dosage 500 MCG/ML Quantity 1 ml Location Near 77381 Pricing Drug Information Drug Interactions Images Videos This medicine does not protect you or your partner against HIV infection (AIDS) or any other sexually transmitted diseases. information highlighted below and resubmit the form. Men should inform their doctors if they wish to father a child. If necessary, this product may also be stored at room temperature below 86 degrees F (30 degrees C) for up to 14 days. By expanding blood stream to the penis, alprostadil assists speed up an erection. After you have administered MUSE, it is important to sit, or preferably stand or walk about for 10 minutes while the erection is developing. In human studies using Doppler duplex ultrasonography, intraurethral administration of 500 mcg of MUSE resulted in an increase in cavernosal artery diameter and a 5- to 10-fold increase in peak systolic flow velocities. Also, your erection may continue after orgasm. To report side effects, contact Meda Pharmaceuticals Inc. at 1-888-367-6873 or contact FDA at 1-800-FDA-1088, fax 1-800-FDA-0178 or online at www.fda.gov/medwatch/report.htm. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. Please review the video and patient starter booklet available from your doctor which illustrates various positions that will enhance your erection. alprostadil 1000 MCG Urethral Suppository is also used to improve blood flow in newborn babies with a certain genetic heart condition. When used via a suppository, it works the same way as when it is injected. 996 patients (66% of those who began titration) were studied during the home treatment portion of 2 Phase III placebo-controlled studies. 1 in 1 POUCH; Type 9: Other Type of Part 3 Combination Product (e.g., Drug/Device/Biological Product), 1 in 1 POUCH; Type 0: Not a Combination Product. Patients and partners who use MUSE should be counseled about the protective measures that are necessary to guard against the spread of sexually transmitted agents, including the human immunodeficiency virus (HIV). To report side effects, contact Meda Pharmaceuticals Inc. at 1-888-367-6873 or contact FDA at 1-800-FDA-1088, fax 1-800-FDA-0178 or online at www.fda.gov/medwatch/report.htm. Portfolio. Keep unopened medicine in the pouch. They need to know if you have, or have had any of these conditions: This medicine is for use in the penis only. Wait 10-30 minutes before you have sex. First, urinate. Alprostadil reaches its peak levels within minutes and successful erection is achieved within 5 to 10 minutes. MUSE is a registered trademark of Meda AB, a Mylan company. (alprostadil) Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Talk to your pharmacist for more details. Alprostadil is suspended in polyethylene glycol 1450 (as excipient) and is formed into a medicated pellet (micro-suppository measuring 1.4 mm in diameter by 3 mm or 6 mm in length) that resides in the tip of a translucent hollow applicator. Intraurethral alprostadil (Vivus's MUSE) is an intraurethral medication (i.e., a drug that is injected into the urethra) that was approved by the FDA in June 1998. The most common side effect is pain in the area where you get the shot. The maximum frequency of use is no more than 2 systems per 24-hour period. Before using this medication, tell your doctor or pharmacist your medical history, especially of: penis conditions (such as angulation, cavernosal fibrosis, Peyronie's disease), bleeding disorders, blood system cancers (such as leukemia, multiple myeloma), heart disease, low blood pressure, sickle cell anemia. You can use a small amount of lubricant like KY jelly or Astroglide to . Muse Alprostadil 1,000 mcg Suppository Carton 6 Suppositories Meda Pharmaceuticals 00037814006 Meda Pharmaceuticals 00037814006 - McKesson Medical-Surgical McKesson The inactive ingredient in MUSE is polyethylene glycol 1450, USP. Patients with pulmonary disease therefore may have a reduced capacity to clear the drug. Successful therapy with MUSE was associated with improvement in the quality of life measures of emotional well-being for patients and relationship with partner for both patients and their female partners. The suppository form is called MUSE (which stands for Medicated Urethral System for Erection). If symptoms persist, call your doctor promptly. MUSE is administered by inserting the applicator stem into the urethra after urination. Available Products Muse urethral suppository, Mylan, 1000 mcg, 6 count, NDC 00037-8140-06 For more drug information about Caverject, contact your doctor or pharmacist.Prescription Hope can obtain a Caverject discount for individuals at the set price of $50.00 per month. information is beneficial, we may combine your email and website usage information with You can begin sexual activity, but having the man lie down, especially on his back shortly after administration, is not recommended. Alprostadil is a synthetic form of a normal body chemical, prostaglandin E1, that causes increased blood flow into the penis. Before administering MUSE, please review the patient video and education booklet. During post-marketing surveillance syncope occurring within one hour of administration has been reported. This content does not have an Arabic version. The transurethral absorption of alprostadil after MUSE administration is biphasic. The most common reported side effects observed in women whose partners use MUSE are mild vaginal itching or burning. Do not reuse them! If its not used properly, it can permanently damage the penis. Or you can use it as suppository, placing it into the opening at the tip of the penis. MUSE alprostadil is a vasodilator that you administer directly to your penis as a urethral suppository. Coming to a Cleveland Clinic location?Visitation, mask requirements and COVID-19 information. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, Advanced Prostate Cancer Treatment: Side Effects, List Alprostadil Suppository side effects by likelihood and severity. MUSE is available in the following 4 dosage strengths: Store unopened foil pouches in a refrigerator at 2-8C (36-46F). this savings card may be used to reduce the amount of your out-of-pocket costs for muse (alprostadil) urethral suppository up to a maximum of $50 per 30-day prescription after you pay the first $20 per 30-day prescription for the first fill, and then for subsequent fills, up to a maximum of $50 per 30-day prescription after you pay the first How will it compare to the erections I had when I was younger? What do I need to tell my doctor BEFORE I take Alprostadil Urethral Suppository? In female partners, vaginal burning/itching may occur. In vitro, alprostadil (PGE1) has been shown to cause dose-dependent smooth muscle relaxation in isolated corpus cavernosum and corpus spongiosum preparations. There are several causes, the most common being due to a narrowing of the arteries that take blood to the penis. The enzyme catalyzing this process has been isolated from many tissues in the lower genitourinary tract including the urethra, prostate, and corpus cavernosum. When traveling, store MUSE in a portable ice pack or cooler. Keep unopened medicine in the pouch. MUSE is a transurethral delivery system available in 4 dosage strengths: 125 mcg, 250 mcg, 500 mcg, and 1000 mcg. This will reduce blood flow to the penis and may reduce the erection. After the single-use, the injection device and remaining solution should be discarded. Wipe the tops of the injection bottles with an alcohol swab. In the US - Call your doctor for medical advice about side effects. If you have any additional questions about MUSE, please call the toll free patient information line at Meda Pharmaceuticals Inc. 1-888-367-MUSE (1-888-367-6873), or visit the MUSE product web site, http://www.muserx.net, Distributed by: This site complies with the HONcode standard for trustworthy health information: verify here. The majority of DHK-PGE1 is further metabolized to smaller prostaglandin remnants that are cleared primarily by the kidney and liver. suppository medicine name The mean maximum plasma PGE1 concentration following intraurethral administration of the highest dose of MUSE (1000 mcg) was barely detectable (11.4 picograms/mL). Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. It widens your blood vessels and relaxes the muscles around your penis. (See WARNINGS). An application of ice packs to the inner thigh may shorten the duration of the erection, since the cold will restrict blood flow to the penis. Dont use it more than three times a week. MUSE is contraindicated in men with any of the following: Because of the potential for symptomatic hypotension and syncope, which occurred in 3% and 0.4%, respectively, of patients during in-clinic dosing, MUSE titration should be carried out under medical supervision. In dogs, sperm concentration, morphology, and motility were unaffected by daily intraurethral administration of up to 3000 mcg MUSE (alprostadil) for 13 weeks (200 mcg/kg/day or about 3.5 times the maximum recommended daily dose adjusted for body surface area). At first, you may feel some minor discomfort from insertion. Alprostadil. 2005 - 2022 WebMD LLC. The most common side effects that have been observed using MUSE follow: If you have a history of fainting be sure to discuss this with your doctor prior to using MUSE. WHAT ARE THE POSSIBLE SIDE EFFECTS OF MUSE?. Before you take it, tell your doctor: Also, tell your doctor if you have any medical problems, especially: If you cant take this medicine, your doctor can recommend other treatments. Copyright 2022 Elsevier Inc. All Rights Reserved. There is potential for serious harm to an unborn child. Your dose of MUSE will be determined by you and your physician. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Posted 56 months ago (3/8/2018) 5. After you have administered MUSE, replace the cover on the applicator, place in the opened foil pouch, fold, and discard as normal household waste. MUSE may not create an erection such as those you experienced when you were younger.